2025 Lexus Rx 350 Hybrid Mpg. The rx 350h gets 37 mpg in the city and 34 mpg on the highway, while the rx. Research the 2025 lexus rx 350 at cars.com and find specs, pricing, mpg, safety data, photos, videos, reviews and local inventory.

Interestingly, the larger/heavier rx features the same 2.4l turbo motor as the nx 350. Find all 2025 lexus rx 350 pictures, prices, mpg, comparisons, reviews, specs, safety ratings and much more to help you make an informed car buying decision.